Article
Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jun 2011
Kamide Kei, Kokubo Yoshihiro, Yang Jin, Takiuchi Shin, Horio Takeshi, Matsumoto Sachiko, Banno Mariko, Matayoshi Tetsutaro, Yasuda Hisayo, Miwa Yoshikazu, Yoshihara Fumiki, Nakamura Satoko, Nakahama Hajime, Iwashima Yoshio, Oguro Ryousuke, Ohishi Mitsuru, Rakugi Hiromi, Okamura Tomonori, Miyata Toshiyuki, Kawano Yuhei
Abstract excerpt
Regulator of G-protein signaling 2 (RGS2) is a key molecule in signal pathways of vasoactive peptides, such as angiotensin II and endothelin 1, and is believed to have an important role in the pathophysiology of atherosclerosis. We have previously reported that common polymorphisms of RGS2 are associated with hypertension in Japanese. In this study, we studied whether the three previously identified common...
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