Article
Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Feb 2008
Kohara Katsuhiko, Tabara Yasuharu, Nakura Jun, Imai Yutaka, Ohkubo Takayoshi, Hata Akira, Soma Masayoshi, Nakayama Tomohiro, Umemura Satoshi, Hirawa Nobuhito, Ueshima Hirotsugu, Kita Yoshikuni, Ogihara Toshio, Katsuya Tomohiro, Takahashi Norio, Tokunaga Katsushi, Miki Tetsuro
Abstract excerpt
A multiple candidate-gene approach was used to investigate not only candidate genes, but also candidate pathways involved in the regulation of blood pressure. We evaluated 307 single nucleotide polymorphisms (SNPs) in 307 genes and performed an association study between 758 cases and 726 controls. Genes were selected from among those encoding components of signal transduction pathways, including receptors,...
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