Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new role for cofilin in retinal neovascularization

8 Feb 2016

Abstract excerpt

Pak1 plays an important role in several cellular processes, including cell migration, but its role in pathological angiogenesis is not known. Here, we have determined its role in pathological retinal angiogenesis using an oxygen-induced retinopathy (OIR) model. VEGFA induced phosphorylation of Pak1 and its effector cofilin in a manner that was dependent on time as well as p38MAPKβ (also known as MAPK11) in human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Cellular Mechanics and Interactions
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26857814
DOI: 10.1242/jcs.179382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new role for cofilin in retinal neovascularizationPMID 26857814Read ↗

Atypical p38 Kinase Signaling in Retinal Vascular Damage and RecoverySemantic proximity Read ↗

Repression of choroidal neovascularization through actin cytoskeleton pathways by microRNA-24.Semantic proximity Read ↗

PlGF and VEGF-A/PlGF heterodimer are crucial for recruitment and activation of immune cells during choroid neovascularizationSemantic proximity Read ↗

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal NeovascularizationSemantic proximity Read ↗

The Novel Pathogenesis of Retinopathy Mediated by Multiple RTK Signals is Uncovered in Newly Developed Mouse ModelSemantic proximity Read ↗

Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization ModelSemantic proximity Read ↗

Ligand-independent Activation of Platelet-derived Growth Factor Receptor β promotes contraction of retinal pigment epithelial cellsSemantic proximity Read ↗

Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expressionSemantic proximity Read ↗

Cofilin promotes actin polymerization and defines the direction of cell motility.Semantic proximity Read ↗

TAK1 blockade as a therapy for retinal neovascularizationSemantic proximity Read ↗

The Role and Potential Mechanism of Nuclear Protein PCNP in Retinal Neovascularization in VitroSemantic proximity Read ↗

Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal NeovascularizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.