Article
Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells.
Differentiation; research in biological diversity - 1 Sept 2008
Wirz W, Antoine M, Tag C G, Gressner A M, Korff T, Hellerbrand C, Kiefer P
Abstract excerpt
Hepatic stellate cells (HSCs) are pericytes of liver sinusoidal endothelial cells (LSECs) and activation of HSC into a myofibroblast-like phenotype (called transdifferentiation) is involved in several hepatic disease processes including neovascularization during liver metastasis, chronic and acute liver injury. While early smooth muscle cell (SMC) differentiation markers including SM alpha-actin and SM22alpha are...
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