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Article

p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase.

Experimental cell research - 15 Jul 2005

Lee Jangsoon, Jung In Duk, Chang Won Keun, Park Chang Gyo, Cho Do Yeun, Shin Eun-Young, Seo Dong Wan, Kim Yong Kee, Lee Hyang Woo, Han Jeung-Whan, Lee Hoi Young

Abstract excerpt

Lysophosphatidic acid (LPA) mediates diverse biological responses, including cell migration, through the activation of G-protein-coupled receptors. Recently, we have shown that LPA stimulates p21-activated kinase (PAK) that is critical for focal adhesion kinase (FAK) phosphorylation and cell motility. Here, we provide the direct evidence that p85 beta-PIX is required for cell motility of NIH-3T3 cells by LPA...

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Share to Focal Adhesion Kinase 1
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lysophospholipids

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Source

Identifiers

PMID: 15893751
DOI: 10.1016/j.yexcr.2005.03.028

Genes

LPA
GIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase.PMID 15893751Read ↗

The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration.Semantic proximity Read ↗

Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding.Semantic proximity Read ↗

GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.Semantic proximity Read ↗

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.Semantic proximity Read ↗

Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via α-PIXSemantic proximity Read ↗

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