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Article

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis.

Nature communications - 18 Aug 2016

Martin Katherine, Pritchett James, Llewellyn Jessica, Mullan Aoibheann F, Athwal Varinder S, Dobie Ross, Harvey Emma, Zeef Leo, Farrow Stuart, Streuli Charles, Henderson Neil C, Friedman Scott L, Hanley Neil A, Piper Hanley Karen

Abstract excerpt

Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure. Integrin-dependent interaction with scar ECM promotes pro-fibrotic features. However, the pathological intracellular mechanism in liver myofibroblasts is not completely understood, and further insight could enable therapeutic efforts to reverse fibrosis. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27535340
DOI: 10.1038/ncomms12502
PMCID: PMC4992158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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