Article
The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.
PloS one - 23 Mar 2011
Banks Susan M L, Cho Bomsoo, Eun Suk Ho, Lee Ji-Hoon, Windler Sarah L, Xie Xuanhua, Bilder David, Fischer Janice A
Abstract excerpt
Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin from newly internalized vesicles. Two hypotheses have been advanced to explain the requirement for ligand endocytosis. One idea is that after ligand/receptor...
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