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Article

Auxilin is essential for Delta signaling.

Development (Cambridge, England) - 1 Mar 2008

Eun Suk Ho, Banks Susan M L, Fischer Janice A

Abstract excerpt

Endocytosis regulates Notch signaling in both signaling and receiving cells. A puzzling observation is that endocytosis of transmembrane ligand by the signaling cells is required for Notch activation in adjacent receiving cells. A key to understanding why signaling depends on ligand endocytosis l...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18256200
DOI: 10.1242/dev.009530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18256200-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Auxilin is essential for Delta signaling.PMID 18256200Read ↗

Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway.Semantic proximity Read ↗

The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis.Semantic proximity Read ↗

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.Semantic proximity Read ↗

Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.Semantic proximity Read ↗

Endocytic internalization routes required for delta/notch signaling.Semantic proximity Read ↗

Auxilin, clathrin trafficking and Parkinson's diseaseSemantic proximity Read ↗

Epsin potentiates Notch pathway activity in Drosophila and C. elegans.Semantic proximity Read ↗

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapseSemantic proximity Read ↗

Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytesSemantic proximity Read ↗

Identification of genes that interact with Drosophila liquid facets.Semantic proximity Read ↗

Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division.Semantic proximity Read ↗

Molecular mechanism and physiological functions of clathrin-mediated endocytosis.Semantic proximity Read ↗

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