Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Auxilin is essential for Delta signaling.

Development (Cambridge, England) - 1 Mar 2008

Eun Suk Ho, Banks Susan M L, Fischer Janice A

Abstract excerpt

Endocytosis regulates Notch signaling in both signaling and receiving cells. A puzzling observation is that endocytosis of transmembrane ligand by the signaling cells is required for Notch activation in adjacent receiving cells. A key to understanding why signaling depends on ligand endocytosis lies in identifying and understanding the functions of crucial endocytic proteins. One such protein is Epsin, an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Clathrin
Share to Eye

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Insect

Share to HSC70 Heat-Shock Proteins

Share to Receptors, Notch

Share to Vesicular Transport Proteins

Share to Wings, Animal

Source

Identifiers

PMID: 18256200
DOI: 10.1242/dev.009530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Auxilin is essential for Delta signaling.PMID 18256200Read ↗

Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway.Semantic proximity Read ↗

The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis.Semantic proximity Read ↗

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.Semantic proximity Read ↗

Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.Semantic proximity Read ↗

Endocytic internalization routes required for delta/notch signaling.Semantic proximity Read ↗

Auxilin, clathrin trafficking and Parkinson's diseaseSemantic proximity Read ↗

Epsin potentiates Notch pathway activity in Drosophila and C. elegans.Semantic proximity Read ↗

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapseSemantic proximity Read ↗

Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytesSemantic proximity Read ↗

Identification of genes that interact with Drosophila liquid facets.Semantic proximity Read ↗

Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division.Semantic proximity Read ↗

Molecular mechanism and physiological functions of clathrin-mediated endocytosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.