Article
Endocytic internalization routes required for delta/notch signaling.
Current biology : CB - 23 Mar 2010
Windler Sarah L, Bilder David
Abstract excerpt
The internalization of transmembrane receptors from the cell surface plays a central role in signal regulation. Receptor internalization can occur through different routes; however, because of the difficulty in selectively blocking these routes in vivo, their roles in signaling are poorly understood. Here we use null mutations in Drosophila dynamin, clathrin, and AP-2 adaptor subunits to analyze internalization...
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