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Article

Basal body proteins regulate Notch signaling through endosomal trafficking.

Journal of cell science - 1 Jun 2014

Leitch Carmen C, Lodh Sukanya, Prieto-Echagüe Victoria, Badano Jose L, Zaghloul Norann A

Abstract excerpt

Proteins associated with primary cilia and basal bodies mediate numerous signaling pathways, but little is known about their role in Notch signaling. Here, we report that loss of the Bardet-Biedl syndrome proteins BBS1 or BBS4 produces increased Notch-directed transcription in a zebrafish reporter line and in human cell lines. Pathway overactivation is accompanied by reduced localization of Notch receptor at both...

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Share to ADP-Ribosylation Factors
Share to Cilia
Share to Endosomal Sorting Complexes Required for Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomes

Share to Microtubule-Associated Proteins

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Share to Receptors, Notch

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Source

Open in PubMed Open full text

Identifiers

PMID: 24681783
DOI: 10.1242/jcs.130344
PMCID: PMC4038940

Genes

BBS1
BBS4
ALMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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