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Article

Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway.

The Journal of cell biology - 8 May 2006

Hagedorn Elliott J, Bayraktar Jennifer L, Kandachar Vasundhara R, Bai Ting, Englert Dane M, Chang Henry C

Abstract excerpt

We have isolated mutations in the Drosophila melanogaster homologue of auxilin, a J-domain-containing protein known to cooperate with Hsc70 in the disassembly of clathrin coats from clathrin-coated vesicles in vitro. Consistent with this biochemical role, animals with reduced auxilin function exhibit genetic interactions with Hsc70 and clathrin. Interestingly, the auxilin mutations interact specifically with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16682530
DOI: 10.1083/jcb.200602054
PMCID: PMC2063844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway.PMID 16682530Read ↗

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