Article
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors.
Molecular biology of the cell - 1 Sept 2006
Rusten Tor Erik, Rodahl Lina M W, Pattni Krupa, Englund Camilla, Samakovlis Christos, Dove Stephen, Brech Andreas, Stenmark Harald
Abstract excerpt
The trafficking of endocytosed receptors through phosphatidylinositol 3-phosphate [PtdIns(3)P]-containing endosomes is thought to attenuate their signaling. Here, we show that the PtdIns(3)P 5-kinase Fab1/PIKfyve controls trafficking but not silencing of endocytosed receptors. Drosophila fab1 mutants contain undetectable phosphatidylinositol 3,5-bisphosphate levels, show profound increases in cell and organ size,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.