Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis.

BMC developmental biology - 8 May 2008

Kandachar Vasundhara, Bai Ting, Chang Henry C

Abstract excerpt

BACKGROUND: Ligand endocytosis plays a critical role in regulating the activity of the Notch pathway. The Drosophila homolog of auxilin (dAux), a J-domain-containing protein best known for its role in the disassembly of clathrin coats from clathrin-coated vesicles, has recently been implicated in Notch signaling, although its exact mechanism remains poorly understood. RESULTS: To understand the role of auxilin in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila Proteins
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Membrane Proteins

Share to Photoreceptor Cells, Invertebrate

Share to Protein Structure, Tertiary

Share to Receptors, Notch

Source

Open in PubMed Open full text

Identifiers

PMID: 18466624
DOI: 10.1186/1471-213X-8-50
PMCID: PMC2391152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis.PMID 18466624Read ↗

Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway.Semantic proximity Read ↗

Auxilin is essential for Delta signaling.Semantic proximity Read ↗

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.Semantic proximity Read ↗

Auxilin, clathrin trafficking and Parkinson's diseaseSemantic proximity Read ↗

Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.Semantic proximity Read ↗

Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytesSemantic proximity Read ↗

Endocytic internalization routes required for delta/notch signaling.Semantic proximity Read ↗

Roles of Drosophila deltex in Notch receptor endocytic trafficking and activation.Semantic proximity Read ↗

Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson’s DiseaseSemantic proximity Read ↗

Molecular mechanism and physiological functions of clathrin-mediated endocytosis.Semantic proximity Read ↗

Endocytosis in Drosophila: progress, possibilities, prognostications.Semantic proximity Read ↗

Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.