Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of phorbol ester-induced monocytic differentiation and c-fms gene expression by dexamethasone: potential involvement of arachidonic acid metabolites.

Blood - 15 Sept 1990

Stone R M, Imamura K, Datta R, Sherman M L, Kufe D W

Abstract excerpt

The treatment of human U-937 leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of monocytic differentiation. However, the signaling pathways responsible for induction of the differentiated monocytic phenotype remain unclear. The present studies demonstrate that dexamethasone blocks TPA-induced U-937 cell growth inhibition, adherence, and alpha-naphthyl acetate esterase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Dexamethasone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia

Share to Monocytes

Share to Phenotype

Share to Proto-Oncogene Proteins

Share to Tetradecanoylphorbol Acetate

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 2144778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of phorbol ester-induced monocytic differentiation and c-fms gene expression by dexamethasone: potential involvement of arachidonic acid metabolites.PMID 2144778Read ↗

Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation.Semantic proximity Read ↗

Transient expression of M-CSF is important for osteoclast-like cell differentiation in a monocytic leukemia cell line.Semantic proximity Read ↗

Transforming growth factor beta and dexamethasone cooperatively enhance c-jun gene expression and inhibit the growth of human monocytoid leukemia cells.Semantic proximity Read ↗

C-fms expression correlates with monocytic differentiation in PML-RAR alpha+ acute promyelocytic leukemia.Semantic proximity Read ↗

Selective inhibition of PGE2 production in cells transfected with c-fms encoded CSF-1 receptor genes by the tyrosine kinase inhibitor, ST638.Semantic proximity Read ↗

Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does not inhibit differentiation.Semantic proximity Read ↗

Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.Semantic proximity Read ↗

Induction of Human Matrix Metalloproteinase-12 Gene Transcriptional Activity by GM-CSF Requires the AP-1 Binding Site in Human U937 Monocytic CellsSemantic proximity Read ↗

Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells.Semantic proximity Read ↗

Antisense CD11b integrin inhibits the development of a differentiated monocyte/macrophage phenotype in human leukemia cells.Semantic proximity Read ↗

Gamma interferon augments functional and phenotypic characteristics of vitamin D3-induced monocytoid differentiation in the U937 human leukaemic cell line.Semantic proximity Read ↗

Analysis and quantitation of splicing variants of the TPA-inducible PGHS-1 mRNA in rat tracheal epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.