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Article

Inhibition of phorbol ester-induced monocytic differentiation and c-fms gene expression by dexamethasone: potential involvement of arachidonic acid metabolites.

Blood - 15 Sept 1990

Stone R M, Imamura K, Datta R, Sherman M L, Kufe D W

Abstract excerpt

The treatment of human U-937 leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of monocytic differentiation. However, the signaling pathways responsible for induction of the differentiated monocytic phenotype remain unclear. The present studies demonstrate that dexamethasone blocks TPA-induced U-937 cell growth inhibition, adherence, and alpha-naphthyl acetate esterase...

Topics

Arachidonic Acids
Cell Transformation, Neoplastic
Dexamethasone
Gene Expression Regulation, Leukemic
Humans
Leukemia
Monocytes
Phenotype
Proto-Oncogene Proteins
Receptor, Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tetradecanoylphorbol Acetate

Tumor Cells, Cultured

Source

Identifiers

PMID: 2144778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2144778-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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