Article
Transforming growth factor beta and dexamethasone cooperatively enhance c-jun gene expression and inhibit the growth of human monocytoid leukemia cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1996
Kanatani Y, Kasukabe T, Okabe-Kado J, Hayashi S, Yamamoto-Yamaguchi Y, Motoyoshi K, Nagata N, Honma Y
Abstract excerpt
Glucocorticoids inhibit the proliferation of lymphoid leukemia cells, whereas most myeloid leukemia cells are resistant to glucocorticoids. However, this study showed that glucocorticoids significantly and preferentially inhibited growth of monocytoid leukemia cells in combination with a low conc...
Topics
- Antineoplastic Agents, Hormonal
- Base Sequence
- Cell Cycle
- Cell Division
- Dexamethasone
- Dose-Response Relationship, Drug
- Drug Synergism
- Gene Expression
- HL-60 Cells
- Humans
- Leukemia, Promyelocytic, Acute
- Oligonucleotides, Antisense
- Phenotype