Article
Transient expression of M-CSF is important for osteoclast-like cell differentiation in a monocytic leukemia cell line.
Journal of cellular biochemistry - 1 Jan 1997
Aoki H, Akiyama H, Hosoya H, Souda M, Morioku T, Marunouchi T
Abstract excerpt
Cells of U937, a human monocytic leukemia cell line, differentiate into macrophages by treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA), whereas cells treated with 1 alpha, 25-dihydroxyvitamin D3 [1,25-(OH)2D3] continue to grow without undergoing differentiation. When U937 cells were successively treated with TPA and 1,25-(OH)2D3, tartrate-resistant acid phosphatase-positive multinucleated cells appeared...
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