Article
Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells.
Molecules and cells - 30 Apr 2007
Choi Hee-Jung, Park Young-Guk, Kim Cheorl-Ho
Abstract excerpt
Previously we showed that the human GM3 synthase gene was expressed during the induction of megakaryocytic differentiation in human leukemia K562 cells by phorbol 12-myristate 13-acetate (PMA). In this study we found that treatment of PMA-induced K562 cells with Gö6976, a specific inhibitor of PKC, and U0126, an inhibitor of the extracellular signal-regulated kinase (ERK) reduced expression of GM3 synthase,...
Topics
- 5' Flanking Region
- Androstadienes
- Carbazoles
- Cell Differentiation
- Cyclic AMP Response Element-Binding Protein
- Enzyme Activation
- Extracellular Signal-Regulated MAP Kinases
- Humans
- Indoles
- K562 Cells
- Megakaryocytes
- Mutation
- Neuraminidase
- Phosphatidylinositol 3-Kinases