Article
Sex and genotype determine the selective activation of neurochemically-distinct mechanisms of swim stress-induced analgesia.
Pharmacology, biochemistry, and behavior - 1 Jan 1997
Mogil J S, Belknap J K
Abstract excerpt
A growing literature documents the important influence of organismic factors such as sex and genotype on pain sensitivity and pain modulation. We recently determined that 3-min forced swims in 15 degrees C water produce non-opioid (i.e., naloxone-insensitive) analgesia in outbred Swiss-Webster mice of both sexes; this form of stress-induced analgesia (SIA) is significantly attenuated by the N-methyl-D-aspartate...
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