Article
Mutation of serine 41 in the neuron-specific protein B-50 (GAP-43) prohibits phosphorylation by protein kinase C.
Journal of neurochemistry - 1 Oct 1990
Nielander H B, Schrama L H, van Rozen A J, Kasperaitis M, Oestreicher A B, Gispen W H, Schotman P
Abstract excerpt
The neuron-specific, calmodulin-binding protein B-50 (also known as GAP-43, F1, or neuromodulin) is an endogenous substrate of protein kinase C (PKC). PKC exclusively phosphorylates Ser residues in B-50. As potential phosphorylation sites for PKC, Ser41, Ser110, and Ser122 were indicated, of whic...
Topics
- Animals
- Cloning, Molecular
- GAP-43 Protein
- Membrane Glycoproteins
- Mutation
- Nerve Tissue Proteins
- Peptide Mapping
- Phosphoproteins
- Phosphorylation
- Protein Biosynthesis
- Protein Kinase C
- Rats
- Serine
- Substrate Specificity