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Article

Mutation of serine 41 in the neuron-specific protein B-50 (GAP-43) prohibits phosphorylation by protein kinase C.

Journal of neurochemistry - 1 Oct 1990

Nielander H B, Schrama L H, van Rozen A J, Kasperaitis M, Oestreicher A B, Gispen W H, Schotman P

Abstract excerpt

The neuron-specific, calmodulin-binding protein B-50 (also known as GAP-43, F1, or neuromodulin) is an endogenous substrate of protein kinase C (PKC). PKC exclusively phosphorylates Ser residues in B-50. As potential phosphorylation sites for PKC, Ser41, Ser110, and Ser122 were indicated, of which Ser41 is contained in the sequence ASF, which matches with the sequence of a synthetic PKC substrate. N-terminally...

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Identifiers

PMID: 2144585
DOI: 10.1111/j.1471-4159.1990.tb03159.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutation of serine 41 in the neuron-specific protein B-50 (GAP-43) prohibits phosphorylation by protein kinase C.PMID 2144585Read ↗

Use of a two-hybrid system to investigate molecular interactions of GAP-43.Semantic proximity Read ↗

Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degenerationSemantic proximity Read ↗

Analysis of the role of calmodulin binding and sequestration in neuromodulin (GAP-43) function.Semantic proximity Read ↗

Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species.Semantic proximity Read ↗

N-terminal cysteines essential for Golgi sorting of B-50 (GAP-43) in PC12 cells.Semantic proximity Read ↗

Protein kinase C regulates the phosphorylation and oligomerization of ERM binding phosphoprotein 50.Semantic proximity Read ↗

A point mutant of GAP-43 induces enhanced short-term and long-term hippocampal plasticity.Semantic proximity Read ↗

Identification of calcineurin regulated phosphorylation sites on CRHSP-24.Semantic proximity Read ↗

Calmodulin binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules.Semantic proximity Read ↗

B-50/GAP-43-induced formation of filopodia depends on Rho-GTPase.Semantic proximity Read ↗

Identification in the calcineurin A subunit of the domain that binds the regulatory B subunit.Semantic proximity Read ↗

Lesion-specific pattern of immunocytochemical distribution of growth-associated protein B-50 (GAP-43) in the cerebellum of Weaver and PCD-mutant mice: lack of B-50 involvement in neuroplasticity of Purkinje cell terminals?Semantic proximity Read ↗

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