Article
A point mutant of GAP-43 induces enhanced short-term and long-term hippocampal plasticity.
The European journal of neuroscience - 1 Jun 2002
Hulo S, Alberi S, Laux T, Muller D, Caroni P
Abstract excerpt
The growth-associated protein GAP-43 (or neuromodulin or B-50) plays a critical role during development in mechanisms of axonal growth and formation of synaptic networks. At later times, GAP-43 has also been implicated in the regulation of synaptic transmission and properties of plasticity such as long-term potentiation. In a molecular approach, we have analyzed transgenic mice overexpressing different mutated...
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