Use of a two-hybrid system to investigate molecular interactions of GAP-43.

doi:10.1016/0169-328x(96)00049-6

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Article

Use of a two-hybrid system to investigate molecular interactions of GAP-43.

Brain research. Molecular brain research - 1 Sept 1996

Chao S, Benowitz L I, Krainc D, Irwin N

Abstract excerpt

We used the 'interaction trap' (two-hybrid system) to identify polypeptides that interact with the neuronal phosphoprotein, GAP-43, in an intracellular environment. GAP-43 (neuromodulin, B-50, F1), a protein kinase C (PKC) substrate important for the growth and plasticity of neuronal connections,...

Topics

Calmodulin
Cell Membrane
Chromosome Mapping
GAP-43 Protein
Membrane Glycoproteins
Mutation
Nerve Tissue Proteins
Plasmids

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