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Article

Enhancing Chemotherapy Response with Bmi-1 Silencing in Ovarian Cancer

21 Mar 2011

Abstract excerpt

Undoubtedly ovarian cancer is a vexing, incurable disease for patients with recurrent cancer and therapeutic options are limited. Although the polycomb group gene, Bmi-1 that regulates the self-renewal of normal stem and progenitor cells has been implicated in the pathogenesis of many human malignancies, yet a role for Bmi-1 in influencing chemotherapy response has not been addressed before. Here we demonstrate...

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PMID: 21445297
DOI: 10.1371/journal.pone.0017918

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