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Article

Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1

2 Sept 2016

Abstract excerpt

The evolution of chemoresistance is a fundamental characteristic of cancer that ultimately hampers its clinical management. However, it may be possible to improve patient outcomes significantly by a better understanding of resistance mechanisms, which cancers rely upon during the evolution to an untreatable state. Here we report an essential role of the stem cell reprogramming factor, PBX1, in mediating...

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PMID: 27590741
DOI: 10.1158/0008-5472.can-16-0980

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