Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing of Bmi-1 Gene Enhances Chemotherapy Sensitivity in Human Glioblastoma Cells

1 Jan 2015

Abstract excerpt

BACKGROUND: The aim of this study was to determine the influence of the BMI1 gene on chemotherapy sensitivity in human glioma cells. MATERIAL/METHODS: The expression of the BMI1 gene in 41 cases of human brain glioma was determined by quantitative real-time PCR. The silencing effect of RNA interference on the BMI1 gene was detected by Western blot. Methyl thiazolyl tetrazolium assay (MTT) and flow cytometry...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Hedgehog Signaling Pathway Studies
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25858624
DOI: 10.12659/msm.893754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silencing of Bmi-1 Gene Enhances Chemotherapy Sensitivity in Human Glioblastoma CellsPMID 25858624Read ↗

Targeting of BMI-1 with PTC-209 inhibits glioblastoma developmentSemantic proximity Read ↗

BMI-1, a promising therapeutic target for human cancerSemantic proximity Read ↗

BMI1 as a novel target for drug discovery in cancerSemantic proximity Read ↗

Overexpression of BMI-1 Promotes Cell Growth and Resistance to Cisplatin Treatment in OsteosarcomaSemantic proximity Read ↗

Gremlin1 promotes carcinogenesis of glioma in vitroSemantic proximity Read ↗

Enhancing Chemotherapy Response with Bmi-1 Silencing in Ovarian CancerSemantic proximity Read ↗

Oncoprotein Bmi-1 Renders Apoptotic Resistance to Glioma Cells through Activation of the IKK-Nuclear Factor-κB PathwaySemantic proximity Read ↗

SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell linesSemantic proximity Read ↗

BMI1: A Biomarker of Hematologic MalignanciesSemantic proximity Read ↗

Silencing Bmi1 expression suppresses cancer stemness and enhances chemosensitivity in endometrial cancer cellsSemantic proximity Read ↗

BMI ‐1 promotes breast cancer proliferation and metastasis through different mechanisms in different subtypesSemantic proximity Read ↗

Downregulated the expression of DNMT3B by suppressing PI3K/Akt signaling pathway and enhances the chemosensitivity of glioblastoma to temozolomide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.