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Silencing Bmi1 expression suppresses cancer stemness and enhances chemosensitivity in endometrial cancer cells

20 Sept 2018

Abstract excerpt

BACKGROUND: Bmi1, a polycomb group gene, is essential for self-renewal of stem cells and is frequently upregulated in various cancer cells. We aimed to investigate the effect of Bmi1 silencing on cancer stemness and chemosensitivity in endometrial cancer using targeted siRNA approach in HEC1A and Ishikawa cells. METHODS: Cell viability after treatment with Bmi1 siRNA was assessed using the MTT assay, and cell...

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PMID: 30243092
DOI: 10.1016/j.biopha.2018.09.041

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