Article

Reduced Gene Dosage of Histone H4 Prevents CENP-A Mislocalization in <i>Saccharomyces cerevisiae</i>

2020-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Mislocalization of the centromeric histone H3 variant (Cse4 in budding yeast, CID in flies, CENP-A in humans) to non-centromeric regions contributes to chromosomal instability (CIN) in yeast, fly, and human cells. Overexpression and mislocalization of CENP-A has been observed in cancers, however, the mechanisms that facilitate the mislocalization of overexpressed CENP-A have not been fully explo...

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Literature Corpus work: 2dc4ccab-28d4-55de-9e89-dfd9cdfe2208
DOI: 10.1101/2020.05.29.124032

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