Article
Evidence for Expanding the Role of Streptomycin in the Management of Drug-Resistant Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 20 Aug 2020
Cohen Keira A, Stott Katharine E, Munsamy Vanisha, Manson Abigail L, Earl Ashlee M, Pym Alexander S
Abstract excerpt
In 2019, the WHO tuberculosis (TB) treatment guidelines were updated to recommend only limited use of streptomycin, in favor of newer agents or amikacin as the preferred aminoglycoside for drug-resistant Mycobacterium tuberculosis However, the emergence of resistance to newer drugs, such as bedaquiline, has prompted a reanalysis of antitubercular drugs in search of untapped potential. Using 211 clinical isolates...
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