Demonstration of a splenic cytotoxic effector cell in mice of genotype SCID/SCID.BG/BG.

doi:10.1016/0008-8749(90)90165-n

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Demonstration of a splenic cytotoxic effector cell in mice of genotype SCID/SCID.BG/BG.

Cellular immunology - 1 Oct 1990

MacDougall J R, Croy B A, Chapeau C, Clark D A

Abstract excerpt

Splenocytes from mice of genotype scid/scid.bg/bg were tested in vitro to characterize the nature of the immunological deficit in these doubly mutant animals. The cells were unresponsive to the mitogens LPS and Con A and to alloantigens, as predicted for scid/scid genotype. Splenocytes from scid/scid.bg/bg lysed the NK cell-sensitive target cell line YAC at levels approximately 50% lower than those observed for...

Topics

Animals
Cell Adhesion
Concanavalin A
Cytotoxicity, Immunologic
G(M1) Ganglioside
Genotype
Glycosphingolipids
Immunity, Cellular
Immunologic Deficiency Syndromes
Interleukin-2
Killer Cells, Lymphokine-Activated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Killer Cells, Natural

Lipopolysaccharides

Lymphocyte Activation

Lymphocyte Culture Test, Mixed

Mice

Mice, Mutant Strains

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 2144467
DOI: 10.1016/0008-8749(90)90165-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2144467-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Demonstration of a splenic cytotoxic effector cell in mice of genotype SCID/SCID.BG/BG.PMID 2144467Read ↗

Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.Semantic proximity Read ↗

T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.Semantic proximity Read ↗

Immune deficiency in SCID mice.Semantic proximity Read ↗

Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes.Semantic proximity Read ↗

NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cellsSemantic proximity Read ↗

Characterization of CD4+CD8+ thymocytes observed in SCID-bg mice.Semantic proximity Read ↗

Disparate effect of beige mutation on cytotoxic function between natural killer and natural killer T cells.Semantic proximity Read ↗

Mutations in the p53 and scid genes do not cooperate in lymphomagenesis in doubly heterozygous mice.Semantic proximity Read ↗

TCR beta-independent development of CD4+ CD8+ thymocytes observed in a strain of scid mice.Semantic proximity Read ↗

Scid mouse Pre-B cells with intracellular mu chains: analysis of recombinase activity and IgH gene rearrangements.Semantic proximity Read ↗

Establishment of mouse lymphokine-activated killer cell clones and their properties.Semantic proximity Read ↗

Syngeneic B lymphoma cells provide a unique stimulus to natural killer (NK) cells in genetically low-NK SJL/J mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.