NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells

doi:10.1182/blood-2001-12-0207

Article

NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells

16 Oct 2002

Abstract excerpt

To establish a more appropriate animal recipient for xenotransplantation, NOD/SCID/gamma(c)(null) mice double homozygous for the severe combined immunodeficiency (SCID) mutation and interleukin-2Rgamma (IL-2Rgamma) allelic mutation (gamma(c)(null)) were generated by 8 backcross matings of C57BL/6J-gamma(c)(null) mice and NOD/Shi-scid mice. When human CD34+ cells from umbilical cord blood were transplanted into...

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