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Article

High stability and cooperative unfolding of α-synuclein oligomers.

Biochemistry - 7 Oct 2014

Paslawski Wojciech, Andreasen Maria, Nielsen Søren Bang, Lorenzen Nikolai, Thomsen Karen, Kaspersen Jørn Døvling, Pedersen Jan Skov, Otzen Daniel E

Abstract excerpt

Many neurodegenerative diseases are linked with formation of amyloid aggregates. It is increasingly accepted that not the fibrils but rather oligomeric species are responsible for degeneration of neuronal cells. Strong evidence suggests that in Parkinson's disease (PD), cytotoxic α-synuclein (αSN) oligomers are key to pathogenicity. Nevertheless, insight into the oligomers' molecular properties remains scarce....

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Identifiers

PMID: 25216651
DOI: 10.1021/bi5007833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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