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Article

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase.

Nature genetics - 1 May 2011

Hinkley Trevor, Martins João, Chappey Colombe, Haddad Mojgan, Stawiski Eric, Whitcomb Jeannette M, Petropoulos Christos J, Bonhoeffer Sebastian

Abstract excerpt

The development of a quantitative understanding of viral evolution and the fitness landscape in HIV-1 drug resistance is a formidable challenge given the large number of available drugs and drug resistance mutations. We analyzed a dataset measuring the in vitro fitness of 70,081 virus samples isolated from HIV-1 subtype B infected individuals undergoing routine drug resistance testing. We assayed virus samples...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21441930
DOI: 10.1038/ng.795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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