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Article

Fitness variations and their impact on the evolution of antiretroviral drug resistance.

Current drug targets. Infectious disorders - 1 Dec 2003

Menéndez-Arias Luis, Martínez Miguel A, Quiñones-Mateu Miguel E, Martinez-Picado Javier

Abstract excerpt

The human immunodeficiency virus (HIV) exhibits extensive heterogeneity due to its rapid turnover, high mutation rate, and high frequency of recombination. Its remarkable genetic diversity plays a key role in virus adaptation, including development of drug resistance. The increasing complexity of antiretroviral regimens has favored selection of HIV variants harboring multiple drug resistance mutations. Evolution...

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Identifiers

PMID: 14754435
DOI: 10.2174/1568005033481033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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