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Article

Exploring the complexity of the HIV-1 fitness landscape.

PLoS genetics - 1 Jan 2012

Kouyos Roger D, Leventhal Gabriel E, Hinkley Trevor, Haddad Mojgan, Whitcomb Jeannette M, Petropoulos Christos J, Bonhoeffer Sebastian

Abstract excerpt

Although fitness landscapes are central to evolutionary theory, so far no biologically realistic examples for large-scale fitness landscapes have been described. Most currently available biological examples are restricted to very few loci or alleles and therefore do not capture the high dimensionality characteristic of real fitness landscapes. Here we analyze large-scale fitness landscapes that are based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22412384
DOI: 10.1371/journal.pgen.1002551
PMCID: PMC3297571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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