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Article

A robust TDP-43 knock-in mouse model of ALS

21 Jan 2020

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset degenerative disorder of motor neurons. The diseased spinal cord motor neurons of more than 95% of amyotrophic lateral sclerosis (ALS) patients are characterized by the mis-metabolism of the RNA/DNA-binding protein TDP-43 (ALS-TDP), in particular, the presence of cytosolic aggregates of the protein. Most available mouse models for the basic or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31964415
DOI: 10.1186/s40478-020-0881-5

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