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Article

Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice.

Behavioural brain research - 12 Sept 2011

Hunsaker Michael R, von Leden Ramona E, Ta Binh T, Goodrich-Hunsaker Naomi J, Arque Gloria, Kim Kyoungmi, Willemsen Rob, Berman Robert F

Abstract excerpt

The fragile X premutation is a tandem CGG trinucleotide repeat expansion on the FMR1 gene between 55 and 200 repeats in length. A CGG knock-in (CGG KI) mouse with CGG trinucleotide repeat lengths between 70 and 350 has been developed and used to model the histopathology and cognitive deficits reported in carriers of the fragile X premutation. Previous studies have shown that CGG KI mice show progressive deficits...

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Source

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Identifiers

PMID: 21440572
DOI: 10.1016/j.bbr.2011.03.039
PMCID: PMC3095688

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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