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Article

Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice.

Behavioural brain research - 1 Jul 2014

Renoux A J, Sala-Hamrick K J, Carducci N M, Frazer M, Halsey K E, Sutton M A, Dolan D F, Murphy G G, Todd P K

Abstract excerpt

Fragile X syndrome (FXS) is a common inherited cause of intellectual disability that results from a CGG repeat expansion in the FMR1 gene. Large repeat expansions trigger both transcriptional and translational suppression of Fragile X protein (FMRP) production. Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is an allelic neurodegenerative disease caused by smaller "pre-mutation" CGG repeat expansions that...

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Source

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Identifiers

PMID: 24657592
DOI: 10.1016/j.bbr.2014.03.013
PMCID: PMC4070219

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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