Article
Temporal ordering deficits in female CGG KI mice heterozygous for the fragile X premutation.
Behavioural brain research - 1 Dec 2010
Hunsaker Michael R, Goodrich-Hunsaker Naomi J, Willemsen Rob, Berman Robert F
Abstract excerpt
The fragile X premutation is a tandem CGG trinucleotide repeat expansion on the FMR1 gene between 55 and 200 repeats in length. A CGG knock-in (CGG KI) mouse with CGG repeat lengths between 70 and 350 has been developed and used to characterize the histopathology and cognitive deficits reported in carriers of the fragile X premutation. Previous studies have shown that CGG KI mice show progressive deficits in...
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