Article
Progressive spatial processing deficits in a mouse model of the fragile X premutation.
Behavioral neuroscience - 1 Dec 2009
Hunsaker Michael R, Wenzel H Jürgen, Willemsen Rob, Berman Robert F
Abstract excerpt
Fragile X associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder that is the result of a CGG trinucleotide repeat expansion in the range of 55-200 in the 5' UTR of the FMR1 gene. To better understand the progression of this disorder, a knock-in (CGG KI) mouse was developed by s...
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