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Article

A novel method for detection of mutation in epidermal growth factor receptor.

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2011

Zhao Jinyin, Zhao Jing, Huang Jie, Chen Yan, Jiang Jun, Wu Weili, Wang Pengzhi, Liu Licheng, Li Longyun, Wu Lin, Wang Mengzhao, Chen Weijun

Abstract excerpt

BACKGROUND: For the rapid and sensitive screening of epidermal growth factor receptor (EGFR) hot-spot mutations, we developed a novel method combining mutant-enriched PCR with amplification refractory mutation system (ARMS) TaqMan real-time PCR in a one-step reaction tube. METHODS AND RESULTS: We designed two pairs of primers to enrich and genotyping each mutation (E746_A750del and L858R): nest primers and ARMS...

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Source

Identifiers

PMID: 21439672
DOI: 10.1016/j.lungcan.2011.02.015

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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