Article
Non-invasive detection of EGFR deletion at exon 19 in non-small cell lung cancer by real time diagnostic.
Clinical laboratory - 1 Jan 2014
Sun Hui, Gan Zhi-Chao, Gao Jia-Jia, Zheng Fang
Abstract excerpt
BACKGROUND: The non-invasive identification of epidermal growth factor receptor (EGFR) mutations is important for the institution of individualized therapy of non-small cell lung cancer (NSCLC). In this study, the feasibility of screening for EGFR exon 19 E746_A750del mutations in circulating DNA from plasma was assessed. METHODS: Mutant-specific primers with a Taqman probe (MST-PCR) were designed. The ability of...
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