Article
A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene in non-small-cell lung carcinoma.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 2006
Ohnishi Hiroaki, Ohtsuka Kouki, Ooide Akiko, Matsushima Satsuki, Goya Tomoyuki, Watanabe Takashi
Abstract excerpt
The detection of mutations in the epidermal growth factor receptor (EGFR) gene impacts therapeutic decision-making for non-small-cell lung carcinoma (NSCLC). Although direct sequencing has been most frequently used to detect EGFR mutations, this method displays several disadvantages. We set up si...
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