Article
Detection of EGFR gene mutation in lung cancer by mutant-enriched polymerase chain reaction assay.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2006
Asano Hiroaki, Toyooka Shinichi, Tokumo Masaki, Ichimura Kouichi, Aoe Keisuke, Ito Sachio, Tsukuda Kazunori, Ouchida Mamoru, Aoe Motoi, Katayama Hideki, Hiraki Akio, Sugi Kazuro, Kiura Katsuyuki, Date Hiroshi, Shimizu Nobuyoshi
Abstract excerpt
PURPOSE: Mutations in the epidermal growth factor receptor (EGFR) gene have been reported to be present in non-small cell lung cancer (NSCLC) and related to the responsiveness of tumors to EGFR tyrosine kinase inhibitors, suggesting its usefulness as a biomarker. Because clinical samples contain tumor and normal cells or genes, a highly sensitive assay for detecting mutation is critical for clinical applications....
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