Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms.

Journal of affective disorders - 15 Aug 2013

Halmai Zsuzsa, Dome Peter, Vereczkei Andrea, Abdul-Rahman Omar, Szekely Anna, Gonda Xenia, Faludi Gabor, Sasvari-Szekely Maria, Nemoda Zsofia

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) and bipolar disorder (BPD) have significant genetic predisposition. The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a susceptibility gene for both MDD and BPD. In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3' untranslated region of the P2RX7 gene) were explored in mood disorders. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bipolar Disorder
Share to Case-Control Studies
Share to Depressive Disorder, Major
Share to Genetic Predisposition to Disease
Share to Polymorphism, Genetic
Share to Psychiatric Status Rating Scales
Share to Receptors, Purinergic P2X7
Share to Severity of Illness Index

Source

Identifiers

PMID: 23602648
DOI: 10.1016/j.jad.2013.02.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms.PMID 23602648Read ↗

Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach.Semantic proximity Read ↗

The P2RX7 polymorphism rs2230912 is associated with depression: A meta-analysis.Semantic proximity Read ↗

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.Semantic proximity Read ↗

P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?Semantic proximity Read ↗

P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts.Semantic proximity Read ↗

Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis.Semantic proximity Read ↗

P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients.Semantic proximity Read ↗

Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes.Semantic proximity Read ↗

Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders.Semantic proximity Read ↗

The role of purinergic signaling in depressive disorders.Semantic proximity Read ↗

P2X7 Receptor: A Potential Therapeutic Target for Depression?Semantic proximity Read ↗

Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.