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Article

P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms.

PloS one - 1 Jan 2021

Kristof Zsuliet, Eszlari Nora, Sutori Sara, Gal Zsofia, Torok Dora, Baksa Daniel, Petschner Peter, Sperlagh Beata, Anderson Ian M, Deakin John Francis William, Juhasz Gabriella, Bagdy Gyorgy, Gonda Xenia

Abstract excerpt

The P2X purinoceptor 7 (P2RX7) mediates inflammatory microglial responses and is implicated in neuroimmune mechanisms of depression and neurodegenerative disorders. A number of studies suggest that psychosocial stress may precipitate depression through immune activation. Genetic association studies of P2RX7 variants with depression have been inconclusive. However, nearly all studies have focused on only one...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34111150
DOI: 10.1371/journal.pone.0252766
PMCID: PMC8191953

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