Article
Different tumor-derived p53 mutants exhibit distinct biological activities.
Science (New York, N.Y.) - 5 Oct 1990
Halevy O, Michalovitz D, Oren M
Abstract excerpt
In its wild-type form, the protein p53 can interfere with neoplastic processes. Tumor-derived cells often express mutant p53. Full-length mutant forms of p53 isolated so far from transformed mouse cells exhibit three common properties in vitro: loss of transformation-suppressing activity, gain of...
Topics
- Animals
- Cell Transformation, Neoplastic
- Cloning, Molecular
- Humans
- Mice
- Mutation
- Nuclear Proteins
- Plasmids
- Polymerase Chain Reaction
- RNA, Messenger
- Rats
- Transfection
- Tumor Suppressor Protein p53