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Article

Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro.

PloS one - 17 Nov 2009

Kam Yiu-Wing, Okumura Yuushi, Kido Hiroshi, Ng Lisa F P, Bruzzone Roberto, Altmeyer Ralf

Abstract excerpt

BACKGROUND: Entry of enveloped viruses into host cells requires the activation of viral envelope glycoproteins through cleavage by either intracellular or extracellular proteases. In order to gain insight into the molecular basis of protease cleavage and its impact on the efficiency of viral entry, we investigated the susceptibility of a recombinant native full-length S-protein trimer (triSpike) of the severe...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19924243
DOI: 10.1371/journal.pone.0007870
PMCID: PMC2773421

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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