Article
Dominant expression of multiple drug resistance after in vitro X-irradiation exposure in intraspecific Chinese hamster ovary hybrid cells.
Journal of the National Cancer Institute - 6 Jan 1993
McClean S, Hosking L K, Hill B T
Abstract excerpt
BACKGROUND: Exposure of Chinese hamster ovary (CHO) cells to fractionated x irradiation in vitro has led to expression of a distinctive multiple-drug-resistant phenotype. This phenotype is characterized by overexpression of P-glycoprotein without an increase in P-glycoprotein messenger RNA or gen...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents
- Blotting, Western
- CHO Cells
- Cell Fusion
- Colchicine
- Colony-Forming Units Assay
- Cricetinae
- Doxorubicin
- Drug Resistance
- Genes, Dominant
- Glutathione Transferase
- Hybrid Cells
- Membrane Glycoproteins
- Phenotype
- Radiation Genetics
- Verapamil