Article
Characterization of the P-glycoprotein over-expressing drug resistance phenotype exhibited by Chinese hamster ovary cells following their in-vitro exposure to fractionated X-irradiation.
Biochimica et biophysica acta - 6 Jun 1993
McClean S, Whelan R D, Hosking L K, Hodges G M, Thompson F H, Meyers M B, Schuurhuis G J, Hill B T
Abstract excerpt
Exposure of the Chinese hamster ovarian AuxB1 cell line in vitro to fractionated X-irradiation generated sublines designated DXR-10, which proved resistant to multiple drugs and overexpressed P-glycoprotein (Pgp), as judged by Western blotting using the C219 monoclonal antibody. Further characterization of these irradiated DXR-10 sublines has provided evidence for: (i) the expression of cross-resistance to...
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