Article
Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population.
The American journal of clinical nutrition - 1 Jun 2009
Chanson Aurelie, Parnell Laurence D, Ciappio Eric D, Liu Zhenhua, Crott Jimmy W, Tucker Katherine L, Mason Joel B
Abstract excerpt
BACKGROUND: Five genes--UNG, SMUG1, MBD4, TDG, and DUT--are involved in the repair or prevention of uracil misincorporation into DNA, an anomaly that can cause mutagenic events that lead to cancer. Little is known about the determinants of uracil misincorporation, including the effects of single...
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