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Article

Multivariate genome-wide association study models to improve prediction of Crohn's disease risk and identification of potential novel variants.

Computers in biology and medicine - 1 Jun 2022

Garza-Hernandez Debora, Estrada Karol, Trevino Victor

Abstract excerpt

BACKGROUND: Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) that affects the gastrointestinal tract with diverse symptoms. At present, genome-wide association studies (GWAS) has discovered more than 140 genetic loci associated with CD from several datasets. Using the usual univariate GWAS methods, researchers have discovered common variants with small effects. Univariate methods assume...

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PMID: 35306380
DOI: 10.1016/j.compbiomed.2022.105398

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